During her time on Friends, Cox appeared in the high-profile Hollywood films Scream (1996), Scream 2 (1997) and Scream 3 (2000) as the determined and driven reporter Gale Weathers. She met her husband, David Arquette who played her on-screen love interest Dwight "Dewey" Riley, while filming the first Scream film. Both Cox and her husband David will reprise their respective roles from the Scream trilogy in 2011's Scream 4. The movie will be released in theaters April 15, 2011.
Her other films include The Runner, 3000 Miles to Graceland and The Shrink Is In. In late 2003, Cox and Arquette produced one season of the reality television series Mix It Up. The lifestyle show, which aired on the We cable channel, struggled with low ratings and was not renewed for a second season. She also appeared as Wendy Bronson, alongside Adam Sandler in Bedtime Stories.
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